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While we are taking full responsibility for any remaining
2019-09-23
While we are taking full responsibility for any remaining errors and shortcomings of the paper, we would like to thank Dr. Jong-Hyeon Jeong, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, for offering us insight and literature pointers useful in our quest to
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br Discussion EFTs are sarcomas with almost undifferentiated
2019-09-23
Discussion EFTs are sarcomas with almost undifferentiated histologic features, consequently their differentiation from other small, blue, round cell tumors may be difficult. Substantial intracellular Isoxsuprine hydrochloride clinical on PAS stain is a useful diagnostic feature. The addition of C
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Introduction Neuropathic pain occurs in approximately one
2019-09-23
Introduction Neuropathic pain occurs in approximately one-third of patients with diabetes and is refractory to currently available analgesic drugs (Abbott et al., 2011). This painful diabetic neuropathy (PDN) is associated with elevated levels of methylglyoxal (MG; a reactive glucose metabolite) an
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Despite a high affinity for progesterone and a relatively hi
2019-09-23
Despite a high affinity for progesterone and a relatively high affinity for testosterone [7], the binding of progesterone and testosterone to CBG is often disregarded [1], [2], [3]. However, the concentrations of these two hormones varies considerably under both normal physiological and pathophysiol
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Bmp products such as Fig are persistent pollutants
2019-09-21
Bmp7 products, such as 7–9 (Fig. 2), are persistent pollutants that accumulate in the marine environment and can potentially be transferred to the human population via our trophic connections to the oceans (Wan et al., 2009). In addition to potentially addressing the mechanistic curiosities describe
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Sex has been shown to mediate the
2019-09-21
Sex has been shown to mediate the relationship between allelic differences in COMT and behavior (Harrison & Tunbridge, 2008). The COMT promoter region contains 2 estrogen response elements (Xie, Ho, & Ramsden, 1999) that can inhibit the formation of COMT (Jiang, Xie, Ramsden, & Ho, 2003). With regar
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Introduction Hepatocarcinoma is a common and
2019-09-21
Introduction Hepatocarcinoma is a common and aggressive form of cancer (Trad et al., 2017). Due to a high rate of postoperative recurrence and metastasis, the prognosis for HCC remains dismal (Wang et al., 2017a, 2017b). Subclinical metastasis is the major cause responsible for tumor recurrence and
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Recoverin is a kDa retinal
2019-09-21
Recoverin is a 23-kDa retinal protein that binds to calcium. It regulates the kn 47 kinase of rhodopsin during visual transduction within photoreceptor cells. Since the pathogenicity of anti-recoverin antibody is potent, anti-recoverin CAR patients often have progressive visual impairments, charact
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Next we compared the protease specificity of viruses NS GFP
2019-09-21
Next, we compared the protease-specificity of viruses NS116-GFP/AE and NS116-GFP/AT for trypsin, neutrophilic elastase or supernatant of human neutrophils. For later purposes, we determined the viral yield in a co-cultivation system of infected Vero GSK503 with human neutrophils. The NS116-GFP/elas
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br Introduction Esophageal squamous cell carcinoma
2019-09-21
Introduction Esophageal squamous cell carcinoma (ESCC) is one of the most common types of cancer in East Asia and is a leading cause of cancer-related death worldwide.1, 2 Surgery is widely used for treatment in localized disease, where it can provide definitive management and potential cure. Tre
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Hedamycin isolated from Streptomyces griseoruber belongs
2019-09-21
Hedamycin, isolated from Streptomyces griseoruber, belongs to the highly cytotoxic pluramycin class of SMI-4a clinical (Figure 3(c)). It consists of a planar anthrapyrantrione chromophore attached to two amino sugar rings at one end and a bisepoxide-containing side-chain at the other end (Figure 3(c
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Cytokines are small secreted proteins that mediate and regul
2019-09-21
Cytokines are small secreted proteins that mediate and regulate immunity, inflammation, and hematopoiesis. They are produced in response to an immune stimulus. Cytokines regulate the intensity and duration of the immune response by stimulating or inhibiting the activation, proliferation, and/or diff
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Significantly less is known about regulation of phytocystati
2019-09-21
Significantly less is known about regulation of phytocystatin gene expression. A genomic clone corresponding to the barley cystatin Icy gene has been characterized (Gaddour et al., 2001) and the function of its promoter region has been analysed by Martínez et al. (2005b). Bioinformatic analysis of t
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Many filarial species harbor an endosymbiotic bacterium of t
2019-09-21
Many filarial species harbor an endosymbiotic bacterium of the genus Wolbachia. A recent investigation of Wolbachia distribution in 35 filarial species including 28 species and 7 genera and/or subgenera have shown that 37% of them harbor Wolbachia (Ferri et al., 2011). In filarial nematodes, Wolbach
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LIMKi 3 clinical br Introduction Oral contraceptives OCs are
2019-09-20
Introduction Oral contraceptives (OCs) are the most commonly used medication for contraception all over the world and are also used in the treatment of menstrual disturbances and hyperandrogenism in women with polycystic ovary syndrome [1]. The impact of OC steroids on cardiovascular pathophysiol
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