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Hyperactivation of Notch pathway can
2021-09-02
Hyperactivation of Notch1 pathway can give rise to transformation into T-ALL in murine models. In more than 50% of acute T-cell lymphoblastic leukemias oncogenic activating mutations of Notch1 have been detected and inactivation of Notch1 signaling impairs leukemia cell proliferation and promotes ap
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More unusual modifications also regulate DUBs Recent reports
2021-09-02
More unusual modifications also regulate DUBs. Recent reports have illustrated how reactive oxygen species (ROS) can regulate DUB activity 87, 88, 89, 90. ROS can serve as potent signaling molecules by reacting with active site cysteines of tyrosine phosphatases and some cysteine peptidases to form
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Does a universal mechanism for TLS exist
2021-09-01
Does a universal mechanism for TLS exist? Our previous studies using the bacteriophage T4 DNA polymerase generated the model provided in Fig. 7 that quantifies the molecular forces influencing key steps in the polymerization pathway during the replication of a non-instructional versus miscoding DNA
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br Results br Discussion br Conclusions The present
2021-09-01
Results Discussion Conclusions The present study demonstrates that CRF1 receptor-deficiency prolongs whereas CRF2 receptor-deficiency shortens the duration of recognition memory deficits induced by morphine discontinuation, unraveling opposite roles for the two known CRF receptor subtypes i
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br Materials and methods br
2021-09-01
Materials and methods Results Discussion In this study, we have shown that fat body-specific knockdown of the key splicing factors U1-70K and U2AF lead to decreased triglyceride storage phenotypes in larvae. Additionally, there was no accompanying defect in glycogen storage observed in thes
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In this study we reported that over expressed endogenous cen
2021-09-01
In this study, we reported that over-expressed endogenous central ET-1 exerted anti-allodynic and anti-hyperalgesic effects on SNL-induced NP for the first time. Furthermore, we showed that ETA-R mRNA Norfloxacin hydrochloride together with the level of ET-1 was increased in the CNS up to 21days af
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MoAbs targeting the tumourigenic pathways such as
2021-09-01
MoAbs targeting the tumourigenic pathways, such as IGF-1R may theoretically have a dual working mechanism. On the one hand they block pathways having an anti-tumour working mechanism, and on the other hand they may also stimulate an immunological response inducing a reaction of the patients own immu
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On the opposite side sPLA X has also
2021-09-01
On the opposite side, sPLA2-X has also been implicated in the pathology of cancer [167,168]. Human sPLA2-X induces lipid droplet formation in Ras-driven MDA-MB-231 triple-negative breast cancer BIIE 0246 and promotes their survival during nutrient stress. It acts through the products of its enzymati
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ACE also known as Kininase II is an important enzyme
2021-09-01
ACE also known as Kininase II is an important enzyme of the Renin angiotensin UNC1999 system (RAAS) (Novo et al., 1987), it is believed to be a potent blood pressure regulator and also plays a crucial role in activation of the bradykinin receptor via inactivation of bradykinin which works to induce
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In agreement with the evidence on the
2021-09-01
In agreement with the evidence on the Plg-binding function of tapeworm enolases, eukaryotic enolases have been shown to be multifunctional proteins, with other activities besides their role as glycolytic enzymes (Pancholi, 2001). In this respect, several flatworms have been proved to express enolase
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VMD v Humphrey et al was used to analyze the
2021-09-01
VMD v1.9.2 (Humphrey et al., 1996) was used to analyze the MD trajectories, salt bridge interactions and secondary structure information from each frame. Once the model was optimized, the topological diagram and area and volume of protein cavities were analyzed using PDBsum (Laskowski, 2009) and CAS
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MRS 2768 tetrasodium salt br Materials and Methods br Result
2021-09-01
Materials and Methods Results Discussion ROS generated by SFN target many signaling pathways involved in initiating cancer cell death (Sestili and Fimognari, 2015). For example, ROS have been shown to activate both intrinsic and extrinsic caspase cascades in prostate cancer cells (Singh et
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br Multi subunit RINGs There are RING
2021-09-01
Multi-subunit RINGs There are RING-type E3s that exist as multi-subunit assemblies (see Fig. 3B). A striking example is the Cullin RING Ligase (CRL) superfamily [35], which exhibits enormous plasticity in substrate specificity. Each CRL subfamily is characterized by a cullin protein (Cul-1, 2, 3,
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br Methods br Results br Discussion Skin biopsy
2021-09-01
Methods Results Discussion Skin biopsy and microneurography have both been described as useful tools in the diagnosis of PAN, directly identifying peripheral sympathetic fibers without the mediation of specific BWX 46 organs (Donadio et al., 2005, Donadio et al., 2012a, Donadio and Liguori
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br Experimental Procedures br Acknowledgments br Introductio
2021-08-31
Experimental Procedures Acknowledgments Introduction Incessant consumption of fossil fuels brings on global energy crisis and serious environmental concerns. Hence, the researchers have paid considerable attention to alternative renewable bioenergy. Microalgae has been considered as potenti
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