• NCSs are helical proteins containing four EF hand motifs

  2022-03-15

  

  NCSs are α-helical proteins containing four EF-hand motifs with EF1 being incapable of Ca-binding throughout the family (atomic-resolution structure was firstly resolved for recoverin [5]; for review on NCS structure, see [6]). Some of the NCS proteins (i.e. recoverin and KChIP3) have two while othe

• We found few differential effects on lung

  2022-03-15

  

  We found few differential effects on lung function for exposure to mother’s and father’s smoking in relation to GSTM1 and GSTT1. However, effects related to mother’s or father’s smoking may differ because mothers tend to spend greater amounts of time with young children and mothers may also smoke du

• In this study we demonstrated

  2022-03-15

  

  In this study, we demonstrated that while Cu(I) does not affect LPS induced iNOS NU 1025 it inhibits NO release from microglia. Cu(I)-induced GSNOR inhibition and GSNO depletion is more in line with alternative (non-inflammatory) polarization. These results extend our previous findings that Cu(I) e

• Modulation of the cannabinoid system has been reported to ex

  2022-03-15

  

  Modulation of the cannabinoid system has been reported to exert anti-parkinsonian properties through different mechanisms. On one hand, cannabinoids have neuroprotective properties in different rodent models of PD, both through a CB1/CB2 receptor-independent mechanism (Lastres-Becker et al., 2005) a

• Being a facultative intracellular pathogen C

  2022-03-15

  

  Being a facultative intracellular pathogen, C. pseudotuberculosis is exposed to oxygen and nitrogen species (ROS and RNS, respectively) reactive environment within macrophages (Nathan and Shiloh, 2000), apart from species endogenously generated by metabolic processes. These molecules interact with D

• cl pdx receptor In this study we find that DH CBD induces

  2022-03-15

  

  In this study, we find that DH-CBD induces analgesic effects on inflammatory but not acute pain and the cl pdx receptor level of spinal α1 GlyRs increased after CFA paw injection. These results suggest that GlyR α1 is only involved in chronic pain. A possible explanation is that once the expression

• br Methods and materials br Results To examine the fear

  2022-03-14

  

  Methods and materials Results To examine the fear conditioning effects of the pre-exposure, drug, and sex factors in the total latency time, a 2 × 3 × 2 three-way ANOVA indicated that SCH772984 HCl significant differences occurred in the drug (F2109 = 14.44, p 0.05) and pre-exposure × sex (F

• In a previous study M

  2022-03-14

  

  In a previous study (Möykkynen et al., 2003), we reported that ethanol lengthens the time needed for the AMPA receptors to recovery from desensitization in isolated hippocampal neurons. Here, we did not observe any effect of ethanol on recovery from desensitization in recombinant homomeric GluR-D re

• In this present study the availability of commercial GLUT

  2022-03-14

  

  In this present study, the availability of commercial GLUT and SGLT Vancomycin hydrochloride synthesis directed against different epitopes, enabled us to screen for members of the SGLT family and compare the expression patterns of GLUTs and SGLTs in the different regions of the rat lens. Based on th

• To directly address whether pharmacological attenuation of p

  2022-03-14

  

  To directly address whether pharmacological attenuation of physiological GIP provides therapeutic benefits in obese mice, we pursued a selective long-acting antagonist to complement the work we report on GIPR agonism. We report a GIP analog of sufficient aqueous solubility that employs a shortened N

• Murine models of sickle disease have been valuable tools in

  2022-03-14

  

  Murine models of sickle disease have been valuable tools in the study of human SCD pathogenesis [15], [16], and will continue to be central to development of novel approaches to disease treatment. The SAD mouse model of sickle disease is particularly remarkable for its erythrocyte dehydration pheno

• Inflammatory pain is very common in the

  2022-03-14

  

  Inflammatory pain is very common in the clinic. A study demonstrated that galanin was upregulated after nerve injury or inflammation (Ma and Bisby, 1997). It has been reported that galanin plays an important role in the transmission of nociceptive information in the spinal cord of rats with inflamm

• Of note the intracellular egg

  2022-03-14

  

  Of note, the intracellular egg compartment exhibiting SA-β-gal activity also exhibits lipofuscin auto-fluorescence (Fig. 6B), and it is co-stained with the lipid-specific dye SBB (Supplemental Fig. 5). On the one hand, these findings reflect the fact that the pool of yolk protein contains lipoprotei

• Previous research has suggested that differences in spatiote

  2022-03-14

  

  Previous research has suggested that differences in spatiotemporal regulation of intracellular signaling pathways can confer specificity to cellular responses (Marshall, 1995). Conventional approaches based on gain- or loss-of-function genetic manipulations or small-molecule inhibitors, however, lac

• Alverine Citrate br Methods and materials br Results br Disc

  2022-03-14

  

  Methods and materials Results Discussion In this study we demonstrate that CF epithelial Alverine Citrate exhibit features of apoptosis in their basal, unstimulated state including increased caspase (-3 and -8) activation compared to non-CF epithelial cells. Analysis of factors responsible

15231 records 480/1016 page Previous Next First page 上5页 476477478479480 下5页 Last page