• SAR around amino derivative revealed a number of interesting

  2022-04-16

  

  SAR around amino-derivative revealed a number of interesting trends related to the serum shift and in vitro activity (). A comparison of derivative , and its epimer , showed that the stereochemistry had little effect on the serum shift and the intrinsic affinity for the receptor. In contrast, re-p

• TDG furthermore is inhibited in

  2022-04-16

  

  TDG, furthermore, is inhibited in its excision of U on the NCP relative to duplex, though not to the same extent as SMUG1. There is no significant difference between TDGFL and TDG82−308, consistent with a previous report that the N- and C-termini missing from TDG82−308 do not affect the excision of

• br Acknowledgements br Introduction Obesity is

  2022-04-16

  

  Acknowledgements Introduction Obesity is a growing pandemic, which becomes a global public health problem. The evidence has been readily available and mounting, demonstrating that obesity increases incidences of chronic comorbidities, such as non-alcoholic fatty liver diseases, diabetes, cardi

• About epilepsy no specific seizure type has

  2022-04-15

  

  About epilepsy, no specific seizure type has been identified because GLUT1-DS is associated with a wide range of epilepsies: patients develop seizures in infancy and early childhood, which are, frequently, do not respond to anticonvulsant medication. In infants, seizures are described as brief, subt

• br Competing interests br Acknowledgements

  2022-04-15

  

  Competing interests Acknowledgements Introduction - Factors Regulating Glucose Tolerance Strictly speaking, the incretin effect refers to the amplification of insulin secretion, which occurs when kainic acid is taken in orally as compared to infused intravenously [1]. Normally, the insulin

• While ghrelin s role in addictive

  2022-04-15

  

  While ghrelin's role in addictive behaviors has been most extensively explored with alcohol, ghrelin has also been implicated in biobehavioral substrates of other drugs of abuse. For example, preclinical experiments suggest that GHS-R1a blockade may improve nicotine [155,156], opioids [[157], [158],

• Our own search towards aryl imidazole derived GSMs led to

  2022-04-15

  

  Our own search towards aryl-imidazole derived GSMs led to the discovery of the benzimidazole derivative (). It is one of the most potent GSMs to date, suffering however from sub-optimal drug-like properties. More recently, we have described the design and synthesis of bicyclic triazolo-derivatives,

• br Conclusion In the present study

  2022-04-15

  

  Conclusion In the present study, we found that the majority of commercially available antibodies and antibody-based tools against galanin and its receptors that we tested do not meet validation requirements. Therefore, critical validation of these tools by the user is essential before being used

• br Competing interests br Authors contributions br

  2022-04-15

  

  Competing interests Authors contributions Transparency document Introduction Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver diseases ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), which may further progress to liver cirrhosis and liver carcinoma

• In analyzed alleles in this

  2022-04-15

  

  In 3/11 analyzed Ezetimibe in this study, the c.472C>T missense variant was detected. This variant was previously reported in Malaysian, French, Indian and Pakistani patients (Bhai et al., 2018; Ijaz et al., 2017; Lebigot et al., 2015; Moey et al., 2018; Ngu et al., 2014) who were homozygous and co

• br Materials and methods This is a retrospective case contro

  2022-04-15

  

  Materials and methods This is a retrospective case-controlled study. The cases were selected based on the presence or absence of preeclampsia. Women enrolled in the study delivered singleton pregnancies at our institution from June 2003 to July 2004. Preeclampsia is defined as elevated blood pres

• The primary cancer lesion was mostly in the

  2022-04-15

  

  The primary cancer lesion was mostly in the uterus and adnexa, followed by the gastrointestinal tract, brain, blood, and kidney and Rapalink-1 (Fig. 2A). Histopathological findings indicated that most cancers were adenocarcinomas, followed by squamous cell carcinomas, glioblastomas, malignant lymph

• The root of Danshen has been widely

  2022-04-15

  

  The root of (Danshen) has been widely used as traditional Chinese medicine for many years and shown to exhibit significant pharmacological activities for a variety of human diseases including cancers. Tanshinones, the major active components, belong to a group of an abietane-type diterpenes contain

• In an RNAi screen to interrogate the function of

  2022-04-15

  

  In an RNAi screen to interrogate the function of transmembrane proteins in ISCs/EBs, we identified the SJ protein tetraspanin 2A (Tsp2A) as a tumor suppressor. Further characterization reveals that Tsp2A expression initiates in ISCs and Tsp2A protein assembles at the SJs in the progenitor N-acetyl D

• br Conflict of interest br Introduction Endometriosis is

  2022-04-15

  

  Conflict of interest Introduction Endometriosis is defined as the presence of endometrial glands and stroma outside the uterus, most often in the pelvic peritoneum and ovaries. This disorder affects an estimated 10% of women in the reproductive age group and is basically an estrogen-dependent

15222 records 457/1015 page Previous Next First page 上5页 456457458459460 下5页 Last page