• Adaptaquin br Materials and methods br Results Table present

  2024-01-04

  

  Materials and methods Results Table 1 presents the metabolic phenotype of obese minipigs. After 60 d of HFHS feeding, minipigs not only showed an increased body weight (+45%), but also a perturbed Adaptaquin homeostasis, with higher insulin levels (about +2-fold), HOMA-IR (+5.5-fold), and HOMA

• br Introduction Breast cancer is

  2024-01-04

  

  Introduction Breast cancer is the most frequently occurring cancer in women, and despite the development of new therapies there has been little decline in the mortality rate over the past decade (Siegel et al., 2015). This is partly due to the genetic diversity of breast cancers, such that there

• Ginsenosides are the major bioactive constituents of the

  2024-01-04

  

  Ginsenosides are the major bioactive constituents of the Panax ginseng root, which contain many types of ginsenosides including Rb1, Rg1, Rc, and Rg3. The ginsenoside Rb1 appears to be the most abundant of the bioactive ginsenosides [15]. Rb1 exhibits antiinflammatory, anticarcinogenic, and antioxid

• br Glioblastoma GBM is the highest grade glioma Grade

  2024-01-04

  

  Glioblastoma GBM is the highest-grade glioma (Grade IV) according to WHO classification and belongs to the most malignant form of p-nitro-Cyclic Pifithrin-α tumor. It is an incurable disease despite the use of aggressive treatments that include surgery and radiotherapy, usually in combination wi

• Moreover our results indicate that ADP is by

  2024-01-04

  

  Moreover, our results indicate that ADP is by far a better phosphate donor than AMP (Table 2). Yet, the bindings of AMP and ATP are mutually exclusive, whereas the bindings of ADP and ATP are additive (Fig. 7). The multiplicity of the phosphate donors in the TgAK reaction (Tables 1 & 2), suggests th

• ADA catalyzes the deamination of

  2024-01-04

  

  ADA catalyzes the deamination of adenosine and deoxyadenosine into their respective inosine nucleoside (Cristalli et al., 2001). This conversion is an initial step in a series of reactions responsible for lymphocyte proliferation and differentiation. Moreover, ADA is considered an indicator of cellu

• Introduction The cytoskeleton allows cells to

  2024-01-04

  

  Introduction The cytoskeleton allows cells to establish, maintain and transform their shape. In neurons, these include cell differentiation, migration, polarization and development of their unique arborization. Axons are very thin (~1 μm), long (up to 1m) and highly branched (>95% of the plasma mem

• br Experimental Procedures br Acknowledgments br

  2024-01-04

  

  Experimental Procedures Acknowledgments Introduction Synapses are fundamental units for efficient communication between neurons and their target cells. Despite significant progress in understanding the structure of matured synapses, less is known about the mechanisms by which neurotransmitt

• The LO has so far only

  2024-01-03

  

  The 15-LO-1 has so far only been found in humans and rabbit reticulocytes [3], [20] and the rabbit 15-LO-1 protein demonstrate 81% identity to the human 15-LO-1. However, rabbit monocytes express an enzyme with mainly 12-LO activity [20], [21]. The high degree of sequence conservation between these

• Furthermore low affinity sites that share no structural homo

  2024-01-03

  

  Furthermore, low-affinity sites that share no structural homology with the aforementioned sites have been described in the transmembrane domain. It has been discovered that, in α1βγ2 receptors, potentiation of GABA-activated currents by high concentrations of diazepam is biphasic, with a high- and a

• br Experimental section br Acknowledgments br Introduction A

  2024-01-03

  

  Experimental section Acknowledgments Introduction Adipose is a major endocrine organ which releases a range of bioactive agents [1]. Selected adipose depots have been established as sites of sex steroid metabolism [1]. Subcutaneous and visceral adipose express high levels of aromatase, cap

• To further investigate the role

  2024-01-03

  

  To further investigate the role of cholesterol in the Rh2-induced cytotoxicity, we then focused on the U937 cell line, which is cholesterol auxotroph and considered as a valuable model to study the importance of cholesterol in membrane structure and function (Billheimer et al., 1987), and used the e

• To further address the mechanism of Didox s suppressive

  2024-01-03

  

  To further address the mechanism of Didox’s suppressive effects on mast cell activation, FceRI receptor ekb mg and downstream transcription factor induction were assessed. We found that Didox had no effect on FceRI surface expression, and thus concluded that Didox effects must be occurring downstre

• Perhaps the first evidence of AMPKs

  2024-01-03

  

  Perhaps the first evidence of AMPKs therapeutic ability in DM1 came from Thomas Cooper’s laboratory where they demonstrated that insulin-independent glucose uptake was unaffected in human DM1 muscle γ-Linolenic Acid methyl ester treated with MET, an AMPK activator and first-line therapy for type 2 d

• Several enzymes in serine and

  2024-01-03

  

  Several enzymes in serine and glycine metabolism have been proposed as biomarkers for cancer stage and prognosis. Phosphoglycerate dehydrogenase (PHGDH), phosphoserine phosphatase (PSPH), and serine hydroxymethyltransferase (SHMT) levels are high in TNBC and low in luminal-A breast cancers (Kim et a

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